Pulmonary Hypertension, Tricuspid Regurgitant Velocity Screening, and the Nitric Oxide Pathway
نویسندگان
چکیده
منابع مشابه
Nitric oxide and pulmonary hypertension
Pulmonary hypertension is a serious complication of a number of lung and heart diseases that is characterized by peripheral vascular structural remodeling and loss of vascular tone. Nitric oxide can modulate vascular injury and interrupt elevation of pulmonary vascular resistance selectively; however, it can also produce cytotoxic oxygen radicals and exert cytotoxic and antiplatelet effects. Th...
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Background and purpose: Hypertension is a global health challenge due to its high prevalence and increased risk of cardiovascular disease. It is a multifactorial disease in which both genetic and environmental factors are involved. So far, a number of genes and pathways have been proposed to be associated with HTN, including the nitric oxide/cGMP pathway. To further clarify the role of NO /cGM...
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Objective(s): An increase in nitric oxide (NO) production has been reported in cirrhotic cardiomyopathy and, portal hypertension. Since minocycline has been shown to inhibit NO overproduction, we aimed to examine its role in a rat model of CCl4-induced cirrhotic cardiovascular complications. Materials and Methods: Portal pressure and inotropic responsiveness of isolated papillary muscles to is...
متن کاملInhaled nitric oxide in persistent pulmonary hypertension of the newborn.
Nitric oxide (NO) has vasodilatory effects on the pulmonary vasculature in adults and animals. We examined the effects on systemic oxygenation and blood pressure of inhaling up to 80 parts per million by volume of NO at FiO2 0.9 for up to 30 minutes by 6 infants with persistent pulmonary hypertension of the newborn (PPHN). In all infants this treatment rapidly and significantly increased preduc...
متن کاملNitric oxide, oxygen, and prostacyclin in children with pulmonary hypertension.
OBJECTIVE To test the vasodilatory response of the pulmonary vascular bed in children with pulmonary hypertension. DESIGN Prospective dose response study in which the effects of inhaled nitric oxide (NO) are compared with those of oxygen and intravenous prostacyclin. PATIENTS AND INTERVENTIONS The vasodilator test was performed in 20 patients in whom mean pulmonary artery pressure (PAPm) wa...
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ژورنال
عنوان ژورنال: Hematology
سال: 2011
ISSN: 1520-4391,1520-4383
DOI: 10.1182/asheducation-2011.1.419